No idea what the best build is, since you can't do everything with one character, and different people will argue that different things are indispensible.
I would say SMG specialists have extremely high damage output due to the fact that they can burst many times per round, and the build synergises well with stealth, dodge, evasion, throwing, traps and lockpicking. However you won't ever be very good at crafting if you invest in all of those skills and will have to rely on stuff you find or buy. Plus you'll have to use light armor and probably also dump constitution, so you'll be a glass cannon for a lot of the game.