In the Coretech Warehouse I set a number of mines up for the waves of mercs to find. When I first started seeing them get damaged, I tried to save the game while they were getting hurt, but I wasn't yet initiated in combat. When I did this the save process failed, it popped up "Error!". Then I waited a sec, tried to save again and it completed.
When I loaded the Save my Avatar picture was a picture of rain drops and the map was gone, just a black screen. Had to load from autosave (no big deal since it's right there) but total save corruption. Never loaded from that slot again.