For now it's necessary to have either lockpicking or hacking skills or even both of them if player dont want to miss huge pile of items during game walkthrough, because there is no other way to open closed containers without those skills. Maybe there is a way to add some alternative ways to open closed doors and boxes? With firearms, for example: player will have to shot some bullets to open the lock with a risk of damaging lock permanently and with ton of noise. The same way with meele weapons, the higher strength character have - the higher chance to open the lock, of course with a chance to damage it permanently and some penalty to weapon durability + alternate way to use crowbar. Chemistry oriented players could use acid or small doses of explosives for the same purposes.
Come on, it should be another way to open those closed doors and footlockers, at least most part of them. Stealth character with high lockpicking skill still will have advantage over the others, because he will be able to open locks without noise and risk of damaging it, skill still be valuable. Perfect example - JA2, where you can shot the lock, you can use crowbar, you can use explosives, you can use brutal force or mechanic skills and lockpicks.