(Possible Spoilers)I used up all the antidotes Cliff gave me fighting the Burrowers to get to his wife. When I realized this I decided to go back and buy more before opening the room his wife was hiding in. When I climb out of the trapdoor Cliff dies, but I figure I can at least save his wife. So I buy more antidote and go back and save his wife. When I give her the antidote, I'm transported to the surface where Cliff's dead-body is talking to his wife. Not even in death will his wife cut him a break.
Poor guy.
Note: But at least I got the EXP and it didn't break the game.