Best chance is in Infusion; setting up the sprite sheets is a tedious process because the same model is screenshotted over and over but with different poses and 8 different directions. For example a character can have a sprite sheet for moving, attacking with a rifle, attacking with a pistol, attacking with a sniper rifle, attacking with a crossbow, attacking unarmed, moving while having a pistol equipped, moving while having a sniper rifle equipped, moving while having a crossbow equipped etc. Setting up the sprite sheet for a grenade launcher would require a bunch of different sprite states (being idle with the grenade launcher, attacking with the grenade launcher etc) that will have to be attached to every humanoid character model in the game that can use guns to avoid janky animations and invisible sprites.
Infusion will have 3D models though, so chances are it will be as easy as setting up the pose and animations that will be used by most humanoid characters.