I made the decision to skip crafting and lockpick/hacking entirely because I'm honestly curious to see how the game plays without them... they seem quite integral to gameplay, especially crafting. Anyway, I'm not very good at build theorycrafting, but I'll post with what I've come up with so far. I invite everyone to poke holes in them!
IMO a psi build has to be it, since not having crafted weapons/armor in endgame could be crippling for other builds, especially crossbows (lack of psi armor and bio consumables will still hurt, but what ya gonna do). The base of the build could be something like this:
STR 3
DEX 3
AGI 3
CON 3
PER 3
WIL 10
INT 6 (for Premeditation and Meditation)
Skills (all max): Thought Control, Psychokinesis, Metathermics, Intimidate (only social skill with a combat benefit)
This leaves 9 stat points and 4 skills.
Tank variant:
STR 3
DEX 3
AGI 3
CON 10
PER 3
WIL 10
INT 8
+ Persuasion, Mercantile, Dodge, Evasion
Feat choices: psi feats, Yell, CON-based survivability feats (Fast Metabolism, Last Stand, Thick Skull)
Medium armor, unarmed with tazers and the occasional EMP/flashbang/molotov for extra control, 0 throwing skill be damned.
This is essentially the same as Nerdcommando's
Psion build, trading the craft skills for talk and evasion skills. It's got good survivability on paper even with crap agility, but essentially zero non-psi options, which makes me a bit leery. Full coverage of social skills AND evasive skills could be pretty nice...
Throwing / dodger variant:
STR 3
DEX 6
AGI 3
CON 7
PER 3
WIL 10
INT 8
+ Throwing, Persuasion, Dodge, Evasion (variation: Pickpocket instead of Persuasion)
Feat choices: psi feats, Yell, Grenadier, Fast Metabolism, Deflection (not going to be wielding any mainhand weapons), maybe Nimble. Trading a point in INT for Three-Pointer doesn't sound like a good idea since this build needs to pump WIL.
Light armor, unarmed with grenades and other throwing items (nets?).
Dodge may work to offset the loss of HP and other defensive potential even considering the low agility, and throwing can give a secondary offense option, though throwing knives are going to be weak due to lowish DEX. Needs too many non-psi feats... and it may be too squishy, especially since crafting infused light armor is not an option.
I also thought about a melee and gun variant, but they would be spread way too thin IMO (gun variant needs PER and DEX/STR, melee variant needs STR/DEX and AGI). Still, if anyone can come up with a workable build that uses guns or melee weapons/fists, it'd be quite welcome!