Play on normal, classic.
Choose one weapon skill, and max it at all times, or combine with another.
Use stealth if you want an easier time preparing for combat.
Use lock pick or hacking or both for extra items, extra access to areas, locations, quest resolution etc.
Crafting - you can play without it, but the best items are crafted, this requires some knowledge of the game though. Mercantile is a bonus, Perception is for more lore.
Attributes - min maxing is a good idea, depending on what you want to play. Ranged will require Perception, Psi Will or Intelligence (or both), Melee Dexterity or Strength.
Feats - focus on what you want to do, this might require some reading in advance (show all feats option then filter).
Examples of simple build guidelines (you can check out the builds section here)
Knife + Stealth
Crossbow + Traps
Assault Rifle + Metal armor (very easy game)
Fists + Stealth
Sledgehammer + Metal Armor
Spear + Tactical Vest with Shield (Iron Grip feat) + all the crafting and Throwing
You also have machete builds, chemical and laser weapon builds, small guns are a ton, snipers... the game is quite huge and definitely has replayability.
