Sometimes, I feel like NPCs should give you more warnings about accessing certain areas. There are two examples I can think of. In the United Stations embassy in the Junkyard, there is a Protectorate Soldier standing right inside, warning you to unequip your weapons when you enter. Now, I don't remember if he forces a dialog with you the first time you enter (if he doesn't, he definitely should), but I think a single warning each time you enter the area with a weapon wouldn't be a bad idea. (The warning should only trigger while you are in that entrance area, of course.)
Another, more severe example (in terms of annoyance, since you probably won't lose much progress if you have autosaves on) is the Foundry prison. Once you enter the room south of the northern corridor, the guards and everyone attack you, even though none of the two guards nor anyone else (not even common sense) gives any indication that the area is off-limits. (In fact, for all I know, maybe I'm just supposed to unequip my weapons there like in the embassy, but I get no indication either way.)