I'm at DC and I started noticing increased zone-transition times. I thought it was the areas or a memory leak, but turns out its the autosaving.
My save folders used to be 10-30mb. Now they are 160mb each, containing ~1100 files. These are created from autosaves every time you zone transition on top of when you save manually, and it has made transitions take up more than 30 seconds for me.
It's not terrible, but its not optimal either. I know games have more stuff to keep track of during the lategame, but it's starting to impact the game here so maybe you can look into tricks to make them smaller