Playing an assassin is not as easy as it was before the nerf. With Taste of Blood and total of 14 DEX it was possible to get the AP cost down to 4 for steel knifes. In case of TiChrome even 12 DEX was enough for that, making builds possible that would have 4 AP per hit, Blitz, Fatal Throw, Ripper AND Survival Instinct - which in case of knifes is really worth it.
Now fastest possible is 6 AP @ 17 DEX for steel knives, and 15 DEX for Tichrome. I haven't played it enough to say for sure but I rate knives to be weakest weapons for now and hope there will get some favor again in the future.
I'm not a fan of melee glass-cannons. They have a naturally higher risk of dying but if you want to play one it's probably best to max DEX (incl food buff) and add both grenade-specific feats.
S 3
D 10 -> 16
A 10
C 3
P 3
W 5
I 5
Recklessness
Sprint
Nimble
Quick Tinkering
Cheap Shot
Fatal Throw
Ripper
Taste for Blood
Critical Power
Three-Pointer
Expose Weakness
Blitz
Grenadier
Weaponsmith
An alternative would be a CON based build: 14 DEX (+1 from the eel), serrated TiChrome blade and tabbis you'd still get down to 6 AP per hit.
S 3
D 10 -> 14
A 6
C 8 -> 9 (at level 20)
P 3
W 5
I 5 -> 6 (at level 24)
Recklessness
Sprint
Nimble
Quick Tinkering
Cheap Shot
Fatal Throw
Ripper
Taste for Blood
Critical Power
Expose Weakness
Cut Throat
Survival Instinct
Opportunist or a grenade feat
Weaponsmith
Unfortunately Thick Skull is one CON point out of reach but you could drop INT to 5 and replace Weaponsmith for it. The usefulness of this is questionable as you won't be able to take it before level 24, unless you prioritize CON over DEX or WILL, which would postpone Ripper or 6 AP attacks to level 24. Another problem here is the lack of skill points for throwing so I'd stick with the 6 INT variant.
In any case Quck Tinkering is too good to be left out.