I think the biggest problem is that if you're a stealth build Tchort is sorta trivialized because you can obliterate the mutagen tanks with TNT whilst sneaking, easily destroy his now perma-dead tentacles, (even if you haven't figured out the mutagen puzzle like I did, it would have been very easy) and then kill him before his creatures can get to you from the other side of the room.
The only way I can see making other playstyles viable in comparison to this is ultra-powerful nades, but I believe we've got plasma grenades-- and an MK III should do around 300ish damage, but that's still nothing on a TNT charge.