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Psychokinesis
Pros: works on everything, arguably the strongest school against a single target. Telekinetic Proxy + Implosion/Telekinetic Punch is just deadly. Force field. Electrokinesis = force lightning. Only school that is effective against robots.
Cons: lacks spammable and AOE psi abilities.
Metathermics
Pros: Fire proc fear. Long range and AOE psi abilites.
Cons: very ineffective against robots, loud (see noise: https://stygiansoftware.com/wiki/index.php?title=Noise)
Yeah, let's argue about "strongest school against a single target", too!
Metathermics "arguably" is the strongest vs single target, because it allows to kill extremely high-health enemies (read - 400% health bosses in Domination) by a certain, rather simple, tactic. Better yet, it allows to do it while preventing 'em using _any_ drugs (which bosses oh so often have in lavish supply)!
Here's how:
- have the boss isolated (by removing any minions if any are present nearby, or waiting for him to be far from any if he/they patrol);
- place a single bear trap near some corner at a spot the boss will be able to run to in a single turn, after you start the combat and hide behind that corner;
- start combat, hide behind the corner, end turn. The boss approaches the corner, but fails to do anything to you, 'cause he triggers your bear trap and stops. If the corner is at just right distance from the boss' initial position, then can do without bear trap at all, too;
- 2nd turn: with 60 AP to spend, use MPs to run right next to the boss, then drop a Toxic Gas grenade (15 AP) at his feet (100% chance, can't miss); then do 2x Cryokinesis (40 AP); then cast Premeditation (if you have it), and then Cryostasis the boss (0...5 AP);
- 3rd, 4th, 5th, 6th turns: observe the boss taking increasingly large amounts of damage from Toxic Gas (which does not break Cryostasis because it's not _direct_ damage), while getting extra damage taken debuff ticking up to +200%;
- 7th turn: finish the boss with a few casts of any damaging ability. Cryokinesis will do if there's nothing better. Each hit doing 3x damage (due to full, 20x stack of Toxic Gas debuff), it likely won't require to burn any cooldowns or consumables to finish the boss. Who still did not use any of his own, too - everything he had we can now loot!
One extra benefit of this technique - it's available very earily in the game. Both abilities are learnable in SGS, and very 1st "proper" (400% health) Dominating boss - which is one in the Water Treatment Plant, - is already doable this way. Just did it with a level 8 Psi (12 Will, max hard-pt Metathermics, +10 Metathermics headband, no other bonuses) - and it took just two Cryokinesis casts to finish the boss. Total psi points spent - 90, which is quite cheap for a boss fight, too.