How has this build been affected by the recent update?
Not much. W2C ammo was nerfed but the nerf wasn't that big. Worst case scenario (Naga Protector, 90% mechanical resistance) -> you deal 25% less damage, so chances are you would need *gasp* 2 turns for 4 Nagas. Ammo crafting quantity nerf is not big deal to pistols which are ammo efficient. On the plus side, high quality super steel fibers are easier to access (and cap is raised), so you may squeeze 1-2 crit chance out of this.
And the mid game after Depot A got easier if you kill Wyatt and his dogs and then rob his still warm, twitching body for that sweet 23% crit chance .44' gun which now gives you one free attack every fight. You monster.