Linux Mint 22.2 - Winetricks from the Software Manager - Good Old Games installation
So the pc doll vanishes, disappears, and otherwise goes away, when movement is initiated. Items have no pictures. No video options except Fullscreen seemed to be the culprit, but I did not exhaust the menu. I switched to Windowed (Borderless) and the player moves just fine, and item icons returned. 
I jumped the gun (you know, the saying when a runner begins the race before it was officially heralded) and did not do any playtesting beyond a few floors in SGS, but by the time I made it to the Omega stations it became obvious that the game is unplayable in this state. Not only are item graphics displayed as blank, making it hard to access them, and the pc is invisible when committing an action or during movement, but npcs and quest or transitional objects will also be invisible, such as the generator at Omega, elevators and ladders, and even if I know where they are located the mouse does not interact with anything. At first I was going to tough it out when I thought it was just item graphics and the pc doll glitching out because I notice that I can save and reload and that might replace some of the graphics but not all. That rathound hermit at Omega for instance, there can be no indication of his presence, no mouse hovering notifying anything and no graphics, but he'll still shoot once the area becomes aggro and remain invisible. I hope this is a feature of the paranoia trait, but this is more extreme than what I considered. Oddity xp, 10 perception, paranoia, snooping, interloper, so far: you see where this is going. I'll just set aside the game until I might find something out.
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